Abstract
Summary
The substitution of 20% alcohol for drinking water of Buffalo rats maintained on an adequate diet demonstrated significant decreases in glucose-6-phosphate dehydrogenase, formiminotransferase, malic and citrate cleavage enzyme activities. This is in contrast to the Charles River and other strains of rats. Liver studies using labeled glucose and acetate indicated that the Buffalo rat is capable of synthesizing approximately twice as much lipid from glucose compared with the Charles River rat. The results suggest that the Buffalo rat has a sensitivity to alcohol related to certain aspects of lipid metabolism not seen in the Charles River rat or other strains.
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