Abstract
Summary
Rabbit granulocytes and human-blood leukocytes (mostly granulocytes) shortened the recalcification time of normal rabbit and human plasmas and human plasmas deficient in Factors VIII, IX, XI and XII but not those deficient in Factors VII and X. While these cells shortened the recalcification time of Factor V deficient plasma they failed to shorten the prothrombin time. Neither did granulocytes shorten the prothrombin time of plasmas deficient in Factors VII and X. Rabbit granulocyte lysosomes resembled the intact parent cells in their effect on normal and deficient plasmas. Rabbit lymphocytes had no detectable procoagulant activity. The minimal procoagulant activity observed with the human lymphocyte suspension may have resulted in part from contaminating granulocytes.
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