Abstract
Summary
Polycythemia (HCT 58%) has been observed in splenectomized Ha/ICR (18%) and DBA/2 (16%) mice infected with a polycythemia-inducing strain (Mirand) of Friend virus. Data presented indicate that hepatic erythropoiesis, perhaps stimulated by the observed elevations in plasma ESF during the postinfection anemia, contributes significantly to the polycythemia. The polycythemic response appears more contingent on the presence of an expandable erythropoietic tissue than on the presence of the spleen per se.
The participation of J. Jividen, A. Bulba, R, Kirchmyer, D. Mickens, and D. Mason is gratefully acknowledged.
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