Abstract
Summary
Effects of repeated administration of lead on DNA synthesis in rat kidneys were investigated by autoradiographic methods. In the epithelium of proximal and distal tubules, three injections of lead (0.05 mg lead/g body wt), given at 2-day intervals, excited successive waves of cellular DNA synthesis, 20-40 times above the normal level. The peak of the initial wave of DNA synthesis occurred 30 hr after the first dose of lead, whereas the peaks of the second and third waves appeared 6 hr after the second and third doses of lead, respectively. After each wave of 3H-thymidine uptake, labeling activity declined to a level that remained approximately 6 times that in control rats.
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