Abstract
Summary
Tritium-labeled human chorionic gonadotropin was administered to superovulated rats. The ovary showed the highest uptake of the organs assayed. The uptake reached a maximal level during the second hr after the administration and declined thereafter. The uptake of [3H]HCG was inhibited when administered with native HCG, suggesting that HCG competed with [3H] HCG.
Ovarian autoradiography showed that the silver grains were localized around the periphery of the luteal cells. The present results suggest that HCG probably acts on the cell membrane of the corpus luteum and only a minute amount, if any, enters the cell.
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