Abstract
Summary
1. Simultaneous administration of BAPN and d-penicillamine in low nontoxic doses produced a significant additive inhibition of cross-bonding in collagen of healing wounds. Additive effect was not observed following administration of high doses of β-aminopropionitrile and d-penicillamine.
2. Toxic signs in rats, including partial alopecia, diarrhea, failure to gain weight, began to appear when the dose of BAPN exceeded 40 mg/100 g body weight/day.
3. Toxicity in rats treated with d-penicillamine was limited to weight loss and was noted when doses greater than 150 mg of d-penicillamine/100 g of body weight/day were administered.
4. These results support the hypothesis that d-penicillamine and BAPN act at different stages in the maturation of collagen and suggest that simultaneous administration of low nontoxic doses of several lathyrogenic agents may be more useful in treating human beings than large doses of a single agent.
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