Insensitivity of the Sheep to Prostaglandins 1

Abstract

Summary

Administration of prostaglandins E₂ and F_2α to near-term pregnant sheep failed to produce any effects on uterine tone and on maternal cardiovascular functions. Like-wise, the administration of these substances to the fetal lamb failed to alter the fetal vascular pressures and cardiac output. It is concluded that the sheep are insensitive to prostaglandins.