Abstract
Summary
Serum and synovial C-reactive protein concentrations were determined in rabbits with induced arthritis to test the hypothesis that this acute phase protein is formed from precursors at sites of inflammation. CRP always appeared later and in lower concentration in synovial fluid than in serum. Similarly, in patients with a variety of ar–thritides, synovial CRP concentration never exceeded values expected as a result of simple passage from blood into synovial space. These findings indicated that CRP is not formed at the inflammatory site. Rather, its formation must occur at sites distant from the site of inflammation, and hence depend on humoral factors.
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