Abstract
Summary
Caffeine directly stimulates catecholamine release from adrenal glands perfused with calcium–free medium. The stimulant effect of caffeine is potentiated by preloading the gland with calcium and also by exposure to thiocyanate. These effects parallel the actions of caffeine on muscle contraction and suggest that catecholamine release can be evoked by mobilization of intracellular calcium.
I acknowledge the valuable technical assistance of Mr. James Edwards.
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