Abstract
Summary
The protective effects of D–glu–cose and diphenylhydantoin (DPH) against alloxan–induced diabetes have been compared. Diphenylhydantoin, at intraperitoneal doses of either 10 or 45 mg/kg and D–glucose at an intravenous dose of 1.0 g/kg were found to afford complete protection against alloxan. An intravenous dose of 0.2 g/kg of D–glucose afforded only partial protection. Since the lower dose of D–glucose produced a greater increase in blood glucose than did the lower dose of DPH, it was concluded that the protective effect of DPH against alloxan can not be explained solely on the basis of the DPH–induced hyperglycemia. The 3–methyl analog of DPH was found to be ineffective in blocking the diabetogenic effect of alloxan. This finding suggests that the interaction between DPH and alloxan may be a reflection of a competition between the two agents for a common binding site on the pancreatic beta cell.
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