Abstract
Summary
The present study has shown that there is a deficiency in the ability of an adrenergic neurone to take up norepinephrine for a period of time after removing the heart from the guinea pig. An increase in intracellular sodium parallels the decrease in uptake. There is a return toward the normal environment upon continued perfusion. These studies have obvious implications in investigations carried out on the effect of drugs and other perturbations on the uptake of norepinephrine.
The authors are grateful to Mrs. Ann Leighton, Miss Mary Brasted and Mrs. Brenda Graham for excellent technical assistance.
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