Effects of Testosterone and Estradiol in Vivo on Hepatic Cortisol Metabolism in Vitro 1

Abstract

Summary

Estradiol inhibited the ability of the liver parenchymal cell to transform Cortisol to reduced metabolites whereas testosterone increased both reductive and oxidative metabolism of cortisol. The stimulatory effect on β–hydroxylation was not due to an increase in cytochrome P–450 content.