Abstract
Summary
Highly purified mouse interferon preparations prepared by different techniques in different laboratories inhibited the mul–tiplication of mouse leukemia L 1210 cells. The dose–response curves of the antiviral activity of interferon and the anticell multiplication activity using a sensitive assay were parallel. Likewise, the kinetics of the appearance of the factor responsible for both activities and the curves of thermal inactiva–tion of this factor were also parallel. It seems reasonable to conclude that interferon itself can inhibit cell multiplication.
I. G. is deeply indebted to Dr. Sidney Farber, Director of the Children's Cancer Research Foundation, Boston, MA for his continued interest and support. K. P. acknowledges the aid of NSF Grant No. G. B.–26515. M. T. is the recipient of an EMBO fellowship.
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