Abstract
Summary
Skin fibroblasts derived from patients with Down's syndrome (trisomy-21) have a significantly decreased number of cumulative cell population doublings (CPD) measured from the initial passage to senescence when compared with cultures from karyotypically normal age-matched controls (40 ± 1.5 vs 51.5 ± 2.0 CPD).
In both instances there is a linear decrease in the cell population doubling rate with increasing passage number. However, the trisomic fibroblasts start with and constantly maintain a lower rate, leading to an earlier cessation of replication.
We would like to acknowledge the expert technical assistance of Miss Susan Martin and Miss Nancy Raab.
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