Abstract
Summary
In adult CBA/Wh mice the incidence and mean latency periods of tumors appearing following infection with MSV were dependent upon the dose of virus inoculated and the immunological state of the host. Animals of reduced immunological competence had a 10-fold higher susceptibility to tumor induction as well as a decreased latency period to tumor appearance compared with controls. Moreover, whereas these tumors regressed in intact adult mice, they tended to grow progressively in immunosup-pressed hosts. These results indicate that the immunological competence of the host is a prime determinant of susceptibility to the oncogenic action of murine sarcoma virus.
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