Abstract
Summary
Rabbits treated with methylprednisolone had decreased levels of aortic proline hydroxylase activity, indicating that glucocorticoids decrease collagen content by affecting the rate of synthesis. The inhibitory effects of methylprednisolone on enzyme activity were reversed by treatment of rabbits with epinephrine–thyroxine. Methylprednisolone which is reported to inhibit aortic sclerosis in cholesterol fed rabbits also did not protect epinephrine–thyroxine treated rabbits from aortic sclerosis.
This work was supported in part by grants from the Connecticut Heart Association, the University of Connecticut Research Foundation, and Rhode Island Heart Association.
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