Abstract
Summary
The effects of thymectomy, splenectomy and 3MC treatment on neoplastic expressions were studied in AKR mice. In the intact and splenectomized mice, 3MC increased the total incidence of neoplastic expression due to the development of sc tumors at the site of 3MC treatment and not to an increase in incidence of leukemia. Thymectomy eliminates leukemia during the nine-month observation period in the trioctanoin vehicle control mice and reduced the incidence of leukemia to 1/18 in the 3MC treated mice. The incidence of 3MC induced sarcomas was not increased by thymectomy even in the absence of leukemia, therefore the total incidence of neoplasia was reduced from 100% to 56%. Both thymectomy and splenectomy reduced the latency period for 3MC sarcoma induction.
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