The Permissiveness of Differentiating Mouse Muscle-Cell Cultures to Infection by Group A Coxsackievirus Types 1 and 5 1

Abstract

Summary

Differentiating primary fetal-mouse muscle-cell cultures have been shown to support the replication of prototype strains of coxsackieviruses A1 and A5. Heretofore, mouse cell cultures had been found to be restrictive to the growth of these agents. Myoblastic elements rather than fibroblasts appeared to be the primary cell type susceptible to infection by those coxsackieviruses of Group A tested.

This investigation was supported in part by U.S. Public Health Service Research Grant AI-03771 from the National Institute of Allergy and Infectious Diseases. We thank Barbara Goldberg and Christine Sturm for competent technical assistance.