Abstract
Summary
The xanthine oxidase inhibitor allopurinol alone or in combination with hypoxanthine and adenine exerted little or no protection against the onset of irreversible shock. However when allopurinol is combined with the above two compounds in addition to inosine, alpha-ketoglutarate and oxalacetate 48 hr survival was increased to 43%. This may be due to prevention of loss of purine bases as well as supply of compounds to stimulate high-energy phosphate production. The effects may also be due to the vasodilator properties of the compounds increasing blood flow and thereby reducing the hypoxic effects.
The author acknowledges the technical assistance of Mrs. Hollie A. Moore. The author expresses his appreciation to Dr. Robert A. Maxwell, Department of Pharmacology, The Wellcome Research Laboratories, Burroughs-Wellcome and Co., Research Triangle Park, NC for the generous supply of sodium allopurinol and for many valuable discussions. Supported by The Wellcome Research Laboratories.
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