Abstract
Summary
Amino-oxyacetic acid (AOAA), chlorpromazine, and Dilantin were examined for their effects on acoustic priming of audiogenic seizures. AOAA administered before priming exhibited a protective effect, increasing the severity of subsequent audiogenic seizures. Dilantin had opposite effects, suggesting that the increase of brain levels of GABA provided by all three agents was not causally related to their effects on priming. Nembutal had an effect similar to that seen with Dilantin, and it was proposed that the active drugs exerted their influence by altering the threshold of the auditory transducer.
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