Abstract
Summary
Dextran released histamine in a selective manner from suspensions of normal rat peritoneal mast cells. Some characteristics of the release reaction are described. The quantity of histamine released by dextran was reduced about 50% by the presence of isoproterenol (10-8 M), epinephrine (10-7 M) or norepinephrine (10-6 M). Propranolol but not phenoxybenzamine abolished the isoproterenol effect. Prostaglandin E1 (10-5 M) also partially inhibited histamine release by dextran. Theophylline and dibutyryl cyclic AMP also produced a dose-related inhibition of the release, which reached 50% effectiveness at about 2 × 10-4 M concentration. Effects of several miscellaneous drugs are also described. The results obtained with the principal drugs indicated that the release reaction might be modulated by cyclic AMP.
I am grateful to Mr. Ronald Adamik for his excellent technical assistance.
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