Abstract
Summary
Prostaglandin F2α was found to increase the lower esophageal sphincter pressure in the intact opossum in vivo. Dose response curves of the effect of PGF2α showed that maximal response occurred with a dose of 4 μg/kg. The maximal response with gastrin pentapeptide occurred with a dose of 2 μg/kg for its action on increasing the lower sphincter pressure.
We thank Dr. John Pike of the Upjohn Company for a generous gift of prostaglandin and the Ayerst Company for gastrin pentapeptide.
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