Effect of Prostaglandin F 2α and Gastrin Pentapeptide on the Lower Esophageal Sphincter 1

Abstract

Summary

Prostaglandin F_2α was found to increase the lower esophageal sphincter pressure in the intact opossum in vivo. Dose response curves of the effect of PGF_2α showed that maximal response occurred with a dose of 4 μg/kg. The maximal response with gastrin pentapeptide occurred with a dose of 2 μg/kg for its action on increasing the lower sphincter pressure.

We thank Dr. John Pike of the Upjohn Company for a generous gift of prostaglandin and the Ayerst Company for gastrin pentapeptide.