Abstract
Summary
The poorly developed lymphoid system of germfree guinea pigs did not prevent the development of contact sensitivity and immunologic tolerance to two simple chemicals, dinitrochlorbenzene and dinitrothiocyanatebenzene. Germfree animals responded in a manner similar to conventionally reared animals when these chemicals were applied to the skin or injected in complete Freund's adjuvant.
We thank Mr. Michael Hooton for his technical assistance and Miss Theresa Wilson for carrying out the serum protein electrophoreses.
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