Abstract
Summary
Leukocyte colonies derived from canine bone marrow show different rates of growth and cytological differentiation when grown in the presence of different serum environments. Minimal formation of mature granulocytes was observed with fetal calf serum (FCS) alone compared to that observed with dog or human serum. The growth kinetics and composition of canine leukocyte colonies are dependent upon the source of colony stimulating activity used. This system may be useful in assessing granulopoietic factors in canine and human serum.
We are grateful to Iola Menna and Delphine Jackson for technical assistance.
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