Abstract
Summary
The effect of indomethacin in altering the anti-mineralocorticoid activity of spironolactone was assessed in the DCA-treated intact and adrenalectomized rat. In the intact rat, simulating a hypermineralocorticoid state, indomethacin was devoid of activity at the renal level in dosages up to 10 mg/kg and also failed to alter the anti-DCA response of spironolactone when combined at dosage ratios as high as 20:1. Indomethacin (ca. 1.7 mg/kg) induced a uniform 50% reduction in urine volume and Na and K excretion in the adrenalectomized rat. In the latter study the anti-DCA response of spironolactone (elevation in urinary Na/K ratio) was unaltered following combined indomethacin treatment. However, a relative oliguria and uniformly low concentration of Na and K was observed with the drug combination.
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