Inhibition of ACTH Induced Cyclic AMP Synthesis in Isolated Rat Adrenal Cells by NPS-ACTH 1

Abstract

Summary

The stimulation of cyclic AMP synthesis in isolated rat adrenal cells prelabeled with ³H-adenine has been studied. Whereas adrenocorticotropin (ACTH) produces a very large increase in cyclic AMP levels, the 0-nitrophenyl sulfenyl derivative (NPS-ACTH) causes only a small increase in cyclic AMP formation. NPS-ACTH also inhibits the ACTH induced cyclic AMP synthesis effectively.