Abstract
Summary
Accumulation (S/M) of PAH and TEA was significantly greater in renal cortical slices from male than female rats. The data suggest, therefore, that the stimulatory effect of testosterone on active secretion of organic anions is not specific, but reflects a more generalized trophic effect on the kidney. The sex difference observed in accumulation of PAH was shown to involve differences in initial uptake rate and runout. It is concluded that the greater PAH S/M ratio exhibited by renal cortical slices from male rats results from a greater rate of uptake which is complemented by a slower rate of runout of the anion.
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