Abstract
Summary
Injection of mice with a lethal dose of endotoxin caused an initial increase in liver phosphoenolpyruvate carboxykinase (PEPCK) activity. This increase was not observed in animals tolerant to endotoxin. A significant decrease in enzyme activity was observed 16 hr after injection, and cortisone did not prevent the fall in activity observed. The decrease in enzyme activity obtained in mice 16 hr after injection with endotoxin was not observed in tolerant mice injected with endotoxin.
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