Abstract
Summary
DMSO, DMAC, and sodium glycerophosphate reduced aggregation of human platelets by ADP, epinephrine, and thrombin. Initial aggregation by ADP and the secondary wave of aggregation associated with the release of platelet ADP were inhibited. DMSO and DMAC with 5% dextrose blocked aggregation as effectively as DMSO or DMAC alone. Platelets exposed to DMSO, DMAC or sodium glycerophosphate and resuspended in PPP free of cryoprotective agents did not aggregate as did platelets exposed to TBS, suggesting that platelets had been irreversibly altered in vitro.
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