Abstract
Summary
Mouse neuroblastoma cells agglutinated in the presence of glycoprotein of plant origin (Con A and wheat germ agglutinin), whereas morphologically differentiated cells induced by 4-(3-butoxy-4-meth oxybenzyl)-2-imidazolidinone (inhibitor of cyclic nucleotide phosphodiesterase) did not. WGA agglutinability is lost earlier than Con A during morphological differentiation of neuroblastoma cells. Trypsin treatment unmasked only a portion of Con A agglutinin receptor sites but did not unmask WGA receptor sites at all. The differentiated cells for the most part did not renew cell division after being treated with trypsin. Dibutyryl cyclic AMP or prostaglandin E1-induced differentiated cells showed agglutination in the presence of Con A and WGA. Thus, it was concluded that changes in the agglutinin sites are not necessarily linked with the morphological differentiation or the growth of neuroblastoma cells in culture.
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