Abstract
Summary
The effect of Nembutal on plasma prolactin levels of ovariectomized rats was investigated in three situations which bring about increased release of the hormone. Prolactin was determined by radioimmunoassay. Nembutal lowered the elevated plasma prolactin in etherized rats. It completely reversed the elevation induced by α-methyl-m-tyrosine, an inhibitor of catecholamine synthesis, and also reduced the elevated levels observed in estrogen-treated animals. The results support the hypothesis that Nembutal blocks the release of a prolactin-releasing factor which is released by ether stress, α-methyl-m-tyrosine and estrogen.
Get full access to this article
View all access options for this article.