Abstract
Summary
Adipose tissue of weanling rats with hypothalamic obesity (VMN) incorporated labeled glycerol into lipids, mainly triglycerides, at a faster rate than control. It is postulated that hyperinsulinemia, an important feature of this obesity syndrome, contributes to the increased utilization of glycerol for lipid synthesis.
The authors are indebted to Dr. Douglas S. Riggs for his suggestions. The technical assistance of Miss Diana Hojnicki, Mrs. Bona Marotta, Mrs. Betty Stone and Miss Patricia Zuber are gratefully acknowledged. This work was supported in part by a Diabetes Training Program, Grant AM 05507, by General Research Support Grant RR 05400 from the General Research Support Branch, Division of Research Resources, NIH, as well as research grants from the National Institute of Health, HD 03331 and AM14118.
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