Abstract
Summary
Phenothiazine derivatives (promazine, triflupromazine, and trifluoperazine) were tested for their effect on the function of the isolated, perfused rat liver. All three drugs at concentrations of 10-4 M or higher led to significant inhibition of bile output, clearance of sulphobromophthalein (BSP) and the biliary excretion of the dye; although, at the lowest concentration (10-4 M) perfusion with promazine (PZ) seemed to lead to lesser impairment of hepatic excretory function than did the other two phenothiazines. The flow rate of perfusate was altered by all drugs at higher concentrations (5 × 10-4 M); the most significant and lasting effect in this respect was that of PZ.
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