Abstract
Summary
Administration of halothane ip to rats pretreated with phenobarbital caused hepatic functional impairment in the immediate postanesthetic period. This impairment was manifested by a significant reduction of hepatic microsomal cytochrome P-450 levels and by a significant prolongation of zoxazola-mine induced paralysis times. Both changes were noted in comparison with anesthetic control values. Similar phenobarbital-halothane-treated animals were killed at 24 hr after anesthesia, and their livers were prepared for histologic evaluation. These livers invariably revealed multiple, discrete foci of parenchymal necrosis; many also displayed patchy subcapsular necrosis, as well. Equal amounts of halothane anesthesia produced neither functional impairment nor hepatic necrosis in rats pretreated with saline instead of phenobarbital.
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