Abstract
Summary
This study demonstrates that glutethimide is as effective as phenobarbital in increasing the specific activity of hepatic bilirubin UDP glucuronyltransferase activity in Sprague–Dawley rats. The data also indicate that the effect is dose-dependent and can be elicited by as little as 4 days of therapy. Both glutethimide and phenobarbital increase enzyme activity to normal levels in heterozygous Gunn rats, but fail to stimulate any activity in homozygous Gunn rats, who presumably lack the genetic capacity to synthesize this enzyme.
Get full access to this article
View all access options for this article.