Abstract
Summary
Rhinovirus type 2 susceptibility to interferon and induction of interferon in human embryonic kidney cell cultures were compared to vesicular stomatitis (VSV) and Newcastle disease viruses, respectively. Rhinovirus was susceptible to interferon but less so than VSV. Rhinovirus was a very poor inducer of interferon even at the highest multiplicity tested (30 PFU/cell). Rhinovirus-induced shutoff of host protein synthesis probably did not account for poor stimulation of interferon as ultraviolet light-inactivated virus failed to induce interferon. Possible role of interferon in rhinovirus illness is discussed.
This study has bten supported by grants from the Tuberculosis and Respiratory Association of California.
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