Abstract
Summary
Chlorphenesin (3-p-chloro-phenoxy-1,2-propanediol) has shown antineoplastic activity in a number of experimental tumor systems, including virus-induced murine leukemias and several transplantable tumors. Therapeutic activity was most evident in neoplasias characterized by a protracted course, and optimal drug effects were manifested well after discontinuance of treatment. The drug was not cytotoxic at therapeutic levels, and had no detectable antiviral activity. Experimental results suggest that chlorphenesin may act by enhancing cell-mediated immune responses of the host. Preliminary clinical trials indicate that chlorphenesin may be of value in the treatment of squamous cell carcinoma of the skin.
We are indebted to Dr. R. H. Gustafson of Wallace Laboratories for antiviral studies, and to Miss Linda Carter, Mrs. Hildreth Danforth, and Mrs. Marilyn Seals for technical assistance. The portion of these studies conducted at the Sloan-Kettering Institute was supported in part by Grant CA-08748 from the National Cancer Institute and by the Elsa U. Pardee Foundation.
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