Abstract
Summary
The rate of procaine hydrolysis was studied in unmodified serum at 37°. It was rapid in man, chimpanzee, Papio anubis, Macaca mulatta, and Macaca nemestrina. It was slow or absent in gibbon, M. radiata, P. cynocephalus, C. aethops, Erythrocebus, Saimiri, and galago. Procaine hydrolysis was rapid in sera from mice and gerbils and was slow or absent in sera from hamsters, rats, rabbits, pigs, ferrets, opossum, guinea pigs, horses, goats, and dogs. Thus rapid hydrolysis of procaine in serum is another pathway of drug metabolism that occurs largely in higher primates.
I appreciate the help of Miss B. Henderson and Mr. A. Jackson with some of the hydrolysis measurements, and Dr. S. Purcell of Smith, Kline, and French, Dr. P. Conti of Merck, Sharp, and Dohme and Dr. Larry Wong of Bionetics Research Labs., Inc. for aid in obtaining sera from the primates.
Get full access to this article
View all access options for this article.