Abstract
Summary
Addition of rabbit serum to PAH-NMN medium (1:6 or 1:12 dilution) enhanced the accumulation of both the organic acid PAH and the organic base NMN by adult rat kidney cortical slices. Addition of rabbit serum to PAH-NMN medium containing rabbit kidney slices stimulated PAH uptake only. Adult rabbit serum retained its stimulatory effect on PAH-NMN accumulation by rat kidney slices after ultrafiltration of the serum, but the stimulatory effect was lost after dialysis, suggesting that low molecular weight substances were responsible for the observed results. These findings suggest that serum composition influences renal organic ion transport. The magnitude and specificity of serum-induced changes in PAH-NMN transport can provide information about the mechanisms involved in renal organic ion transport.
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