Abstract
Summary
Isolated, perfused rat diaphragm has been studied with respect to changes in the rate of uptake of D-xylose. L-arabinose and 3-O-methyl-glucose as influenced by insulin and repetitive muscular contraction in the presence or absence of two inhibitors with differing modes of action, in order to elucidate the question of whether one or more than one mechanism exists for accelerating sugar transport. Evidence from phlorizin and maleimide inhibition of transport of the above three sugars indicates that muscular contraction and insulin accelerate sugar transport by different mechanisms.
The authors thank Dr. M. B. Visscher for his helpful assistance in the preparation of this paper. Crystalline glucagon-free insulin used in these experiments was obtained as a gift from Dr. W. R. Kirtley of Eli Lilly Company, Indianapolis, IN.
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