Abstract
Summary
Effect of various doses of LH on maintenance of pregnancy was examined in the rats hypophysectomized on Day 9. Daily doses of 10 and 25 μg LH were found optimal for the maintenance but doses lower or higher than these were less effective. LH did not maintain luteal function in hypophysectomized-pseudopregnant rats. These results suggest that optimal amount of LH in the presence of conceptus maintains luteal function in early pregnancy, and that high doses of LH stimulate secretion of estrogen more than that of progesterone leading to resorption of fetuses.
The authors thank the Endocrinology Study Section, NIH, Bethesda, MD for the LH used in this study.
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