Abstract
Summary
Six weeks after infection with Schistosoma mansoni both an early (5 hr) and late (24–48 hr) intradermal response were elicited in mice challenged with a soluble schistosomal egg antigen (SEA). Passive transfer experiments showed that three anti-SEA immune reactivities exist in 8 week infected mice: passive cutaneous anaphylaxis due to reagin-like antibodies; an Arthus-type, 5 hr reaction due to circulating antibodies; a delayed (24–48 hr) hypersensitivity reaction dependent on lymphoid cells. The kinetics of immunization indicate that these anti-SEA responses are stage specific for the egg antigen preparation.
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