Stimulation by Synthetic Thyrotropin-Releasing Hormone of Glucose Oxidation in Porcine and Rat Pituitary Slices

Abstract

Summary

Synthetic TRH stimulated the oxidation of glucose-1-¹⁴C to ¹⁴CO₂ at a concentration of 2.5 μg/ml in porcine anterior pituitary slices. This stimulation was not observed in porcine posterior pituitary slices or in rat hemipituitaries. TRH also stimulated the production of ¹⁴CO₂ from glucose-U-¹⁴C in the porcine anterior pituitary. This stimulatory effect of TRH on glucose oxidation was blocked by thyroxine added to the incubation medium at a concentration of 10 μg/ml.