Abstract
Summary
Mice or rats fasted overnight were treated intraperitoneally with ethionine and were killed 2 or 3 hr later. Hepatic polyribosomal disaggregation and decreased in vitro hepatic protein synthesis were observed. The administration of l-tryptophan by stomach tube after ethionine treatment and 1 hr before killing caused a corrective effect on hepatic polyribosomes and protein synthesis. Simultaneous administration of ethionine and tryptophan to fasted rats 1 hr before killing induced a shift of hepatic polyribosomes toward heavier aggregation similar to that observed after administering tryptophan alone.
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