Abstract
Summary
The pH of inflammatory exudates collected at various times from chambers adhered over skin wounds of rabbits with acute alloxan diabetes and acidosis was determined. The H-ion concentrations of blood and exudate were compared with each other and with the inflammatory cell responses of the lesions. A local acidosis, indicated by low exudate pH, was present in all lesions. Significant local acidosis, similar to that observed in the lesions of normal rabbits, was present in the wounds of animals with lesser degrees of blood acidosis. Protracted severe blood acidosis was associated with similar low pH values in blood and exudates. The acute inflammatory cell response was delayed in onset and decreased in intensity in the severely acidotic diabetic animals. In these the presence of a markedly decreased acute inflammatory cell response and of a relatively less marked decrease of exudate pH suggest a possible relationship between the intensity of the acute inflammatory cell response and the H-ion concentration at the site of injury.
The authors are grateful to Miss Hillma Gheesling, Mrs. Julia Schuch and Mrs. Marjorie Lamb for competent technical assistance, and to Mrs. Nancy Lambert for secretarial help.
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