Abstract
Summary
The use of lanthanum hydroxide tracers permitted the demonstration of two distinct types of alterations in the ultrastructural appearance of the glomerular basement membrane in aminonucleoside nephrosis. In some capillary loops an increase in the number and size of lanthanum aggregates were observed, in others portions of the basement membrane measuring in length 600-1000 Å the entire thickness of the membrane appeared to be filled with tracer molecules. It is concluded that the lanthanum method is a useful approach for the demonstration of ultrastructural changes in the basement membrane in instances where the use of conventional electron microscopic techniques fail to do so.
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