Differential Inhibition of Nuclear RNA Polymerases in L Cells Infected with Mengovirus 1

Abstract

Summary

The rate of nuclear RNA synthesis in L cells infected with Mengovirus, as measured by [³H] uridine incorporation, falls precipitously within several hours after infection. This decline in RNA synthesis is paralleled by the preferential, exponential inhibition of one of the two major species of nuclear RNA polymerase, polymerase II. While there is some decline after infection of the other major polymerase, the decay of its activity is less marked and less rapid and evidence is presented which suggests that it is a secondary result of viral inhibition of cellular protein synthesis.