Abstract
Summary
A specific complement-reactive factor derived from cobra venom (CVF) inhibited complement activity, impaired clot retraction, and induced aggregation and release of intracellular constituents in plateletrich plasma or suspensions of washed platelets from guinea pigs, rabbits, dogs, and humans. Platelets from thrombopathic dogs and from a complement deficient (C3) patient responded similarly when mixed with purified CVF; possible explanations for these observations are included.
We are indebted to Mr. Jack Newman, New York University Medical Center, for testing our CVF preparations for the presence of contaminating fibrinolytic enzymes.
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