Abstract
Summary
To determine the effect of phenobarbital administration on intestinal calcium transport by the rat intestine, experiments were performed using an in vitro everted gut sac technique as a measure of transport. The results demonstrate that duodenal and ileal transport are not affected by phenobarbital administration in rats raised on a diet adequate in calcium and vitamin D. Duodenal absorption, however, is suppressed in animals raised on a vitamin D-deficient diet. The administration of phenobarbital does not interfere with the expected rise in calcium transport when vitamin D is administered to vitamin D-deficient animals. The depression of transport produced by phenobarbital in vitamin D-deficient animals appears to be mediated independent of the vitamin D pathway.
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