Abstract
Summary
Lateral cerebral ventricular administration of sodium salicylate (0.25-1.00 mg) and acetaminophen (0.50-1.00 mg) significantly inhibited production of fever by LP injected iv in the cat. Acetaminophen also caused mild but significant hypothermia in the absence of fever. The ability of these antipyretics to antagonize fever produced by LP, and by agents such as bacterial pyrogens which release LP, is most likely due primarily to a central action to inhibit the effect of LP rather than to a peripheral action to alter LP release from leukocytes or to inhibit entry of LP into the central nervous system.
Note added in proof. Since this paper was submitted for publication, evidence for a central antipyretic action of sodium acetylsalicylate against LP-induced fever in the monkey has been reported by Chai, C. Y., Lin, M. T., Chen, H. I., and Wang, S. C., Neuropharmacology 10, 715 (1971).
The authors wish to thank Barbara Coldwell for her assistance with some of these experiments.
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